Biotechnology
Gene editing, cancer biotechnology, regenerative medicine, longevity science and the evidence moving from laboratories into clinical care.
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A Rare Tumour After Gene Therapy Shows Why DNA’s Landing Site Matters
Long-read sequencing linked a vector fragment to an unusually active gene in one child’s tumour. The case illustrates a safety question, not a population risk estimate.
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LB2501 Takes the In-Body CAR-T Route Into a Planned US Trial
Legend’s US trial clearance advances a therapy designed to generate CAR T cells inside the patient. Earlier human data are small, preliminary and separate.
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A Cancer-Fuelling Protein Becomes an Ally When Switched On in T Cells
PPARD can help tumours grow, yet boosting it in immune cells improved cancer control in laboratory models. The cell receiving the signal makes the difference.
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An RNA-Splicing Gene Extends Mouse Lifespan in an Early Longevity Test
A gene-screening platform identified SRSF1 as a longevity candidate. Cells and a small mouse experiment offer a lead, with human safety still untested.
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A DNA Typewriter Reconstructs the Ancestry of 1.28 Million Mouse Cells
A molecular recorder linked cell ancestry with cell identity across a developing mouse embryo. Its scale is striking, but the principal tree comes from one animal and remains incomplete.
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Big Dogs’ Faster Molecular Ageing Puts Jumping Genes Under Scrutiny
A study of dog blood methylation links larger body size to faster molecular ageing. It identifies a possible mechanism to test, rather than a way to extend lifespan.
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ARO-MAPT Lowers a Tau Marker With an Injection Under the Skin
Arrowhead reported sustained reductions in cerebrospinal-fluid tau in healthy volunteers. The early trial tests delivery and target engagement, not whether Alzheimer’s disease improves.
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Anktiva’s Expanded Bladder-Cancer Approval Changes How Evidence Can Travel
The FDA expanded Anktiva plus BCG to high-grade papillary-only bladder cancer, drawing on earlier trial evidence and similarities between related tumour forms.
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Artificial Cells Gain RNA Compartments That Capture Proteins and Pass Signals
Researchers assembled DNA–RNA particles with distinct internal compartments and laboratory signalling functions. The systems mimic selected cell behaviours without becoming living cells.
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Ageing’s Lipid-Length Signal Moves From a Pattern to a Worm Experiment
A cross-species study links ageing to longer lipid chains and tests a lipid-remodelling gene in worms. It opens a research target without establishing a human longevity treatment.
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SurVaxM’s Glioblastoma Signal Faces the Hard Test of an Unmet Overall Endpoint
A Phase IIb glioblastoma vaccine trial reported a survival signal in younger patients, while its overall survival endpoint missed statistical significance.
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Caribou’s CAR-T Wind-Down Shows Why Promising Cells Still Need a Funded Trial
Caribou plans to stop two donor-derived CAR-T programmes, citing financing constraints. The decision closes a development path without settling the technology’s clinical value.